A score at diagnosis for predicting length of remission in childhood acute lymphoblastic leukaemia.
AffiliationMedical Statistics, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
MetadataShow full item record
AbstractThirty-two variables at diagnosis of acute lymphoblastic leukaemia (ALL) were studied in an unselected population-bases series of 209 children. Twelve variables had individually a statistically significant effect on the duration of first remission. A multivariate analysis using data on the 199 children who went into complete remission showed that all significant variation in remission times could be explained by only 3 variables acting simultaneously. These were the total white blood count (WBC) at diagnosis, the Franco-American-British (FAB) classification of blast morphology and the percentage of lymphoblasts with PAS+ coarse granules or blocks. A simple scoring system (for WBC add 1 if less than 20 X 10(9)/1, add 2 if 20 - 50 X 10(9)/1, add 3 if greater than or equal to 50 X 10(9)/1; for L2 or L3 leukaemia add 1; for PAS+ less than 5% add 1) separated patients into risk groups with widely different median lengths of first remission. Application of the risk score improves the prediction of the outcome of treatment, and the clinical trials, allows more accurate stratification, less extensive data collection and simpler analysis.
CitationA score at diagnosis for predicting length of remission in childhood acute lymphoblastic leukaemia. 1980, 42 (6):841-9 Br. J. Cancer
JournalBritish Journal of Cancer
PubMed Central IDPMC2010579
- Prognostic importance of morphology (FAB classification) in childhood acute lymphoblastic leukaemia (ALL).
- Authors: Miller DR, Leikin S, Albo V, Sather H, Hammond D
- Issue date: 1981 Jun
- Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood.
- Authors: Scarffe JH, Hann IM, Evans DI, Morris Jones P, Palmer MK, Lilleyman JS, Crowther D
- Issue date: 1980 May
- Prognostic significance of the revised French-American-British classification for acute lymphocytic leukaemia.
- Authors: Davey FR, Castella A, Lauenstein K, Hubbell C, Oates RP
- Issue date: 1983
- Lack of prognostic value of the periodic acid-Schiff reaction and blast cell size in childhood acute lymphocytic leukemia.
- Authors: Shaw MT
- Issue date: 1977
- The prognostic significance of morphological features in childhood acute lymphoblastic leukaemia.
- Authors: Hann IM, Evans DI, Palmer MK, Morris-Jones PJ, Haworth C
- Issue date: 1979