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dc.contributor.authorDodd, Nicholas J F
dc.date.accessioned2011-12-22T11:33:51Z
dc.date.available2011-12-22T11:33:51Z
dc.date.issued1975-07
dc.identifier.citationElectron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions. 1975, 32 (1):108-20 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid169866
dc.identifier.urihttp://hdl.handle.net/10541/198652
dc.description.abstractThe blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCeruloplasmin
dc.subject.meshElectron Spin Resonance Spectroscopy
dc.subject.meshFemale
dc.subject.meshIron
dc.subject.meshLeukemia, Experimental
dc.subject.meshLeukemia, Myeloid
dc.subject.meshLiver
dc.subject.meshMethemoglobin
dc.subject.meshMice
dc.subject.meshSpleen
dc.subject.meshTransferrin
dc.titleElectron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalBritish Journal of Canceren
dc.identifier.pmcidPMC2024794
html.description.abstractThe blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.


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