Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.
Authors
Dodd, Nicholas J FAffiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, ManchesterIssue Date
1975-07
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Show full item recordAbstract
The blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.Citation
Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions. 1975, 32 (1):108-20 Br. J. CancerJournal
British Journal of CancerPubMed ID
169866PubMed Central ID
PMC2024794Type
ArticleLanguage
enISSN
0007-0920Collections
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