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    Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.

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    Authors
    Dodd, Nicholas J F
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1975-07
    
    Metadata
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    Abstract
    The blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.
    Citation
    Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions. 1975, 32 (1):108-20 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/198652
    PubMed ID
    169866
    PubMed Central ID
    PMC2024794
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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