Pituitary function after treatment of intracranial tumours in children.
AffiliationChristie Hospital and Holt Radium Institute, Manchester
MetadataShow full item record
AbstractPituitary-function tests have been done in twenty-seven patients at various times after treatment in childhood for intracranial tumours not directly involving the hypothalamic-pituitary region. Impaired growth hormone (G.H.) responses to hypoglycaemia and 'Bovril' were found in ten children. There seeems to be progressive impairment in G.H. production with time after treatment. During the first 3 months after neurosurgery no child was found to be G.H. deficient, but the peak G.H. response of this group seemed to be blunted when compared with a control group of children who had been treated for abdominal tumours. The rest of anterior-pituitary function in G.H.-deficient children seems quite normal except for a significantly greater basal thyroid-stimulating hormone (T.S.H.) level and T;S.H. response after thyrotrophin-releasing hormone. Two girls have developed secondary amenorrhoea, and one is G.H. deficient.
CitationPituitary function after treatment of intracranial tumours in children. 1975, 2 (7925):104-7 Lancet
- Letter: Pituitary function after treatment of intracranial tumours in children.
- Issue date: 1975 Aug 2
- Endocrine function in patients with suprasellar and hypothalamic tumours.
- Authors: Korsgaard O, Lindholm J, Rasmussen P
- Issue date: 1976 Sep
- Growth hormone deficiency in children with brain tumors.
- Authors: Shalet SM, Beardwell CG, Morris-Jones P, Bamford FN, Ribeiro GG, Pearson D
- Issue date: 1976 Feb
- A new test for the diagnosis of growth hormone deficiency due to primary pituitary impairment: combined administration of pyridostigmine and growth hormone-releasing hormone.
- Authors: Ghigo E, Imperiale E, Boffano GM, Mazza E, Bellone J, Arvat E, Procopio M, Goffi S, Barreca A, Chiabotto P
- Issue date: 1990 Apr
- [Value of an indicator of the health status of children suffering from a severe illness: exemplified by brain tumors].
- Authors: Galès CL
- Issue date: 2000 May