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    Clinical pharmacology of tamoxifen and N-desmethyltamoxifen in patients with advanced breast cancer.

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    Authors
    Wilkinson, P
    Ribeiro, G
    Adam, H
    Patterson, J
    Affiliation
    Christie Hospital, Withington, Manchester, M20 9BX
    Issue Date
    1980
    
    Metadata
    Show full item record
    Abstract
    Serum concentrations of tamoxifen and its metabolite, N-desmethyltamoxifen (DMT) were determined in six post-menopausal patients with advanced breast cancer. Following a single 10-mg dose PO parent drug was detected in the serum, with a peak concentration of 17.5 ng/ml. Concentrations of the N-desmethyl metabolite were below the limit of detection (less than 2.5 ng/ml). After 21 days' oral therapy with 10 mg b.i.d. the serum concentration of tamoxifen had increased ten fold, while DMT was now present in comparable amounts. Two patients were further studied for a longer time period. There was little change in the serum concentration of tamoxifen, while the DMT increased two fold above its value at 21 days.
    Citation
    Clinical pharmacology of tamoxifen and N-desmethyltamoxifen in patients with advanced breast cancer. 1980, 5 (2):109-11 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/196311
    PubMed ID
    7471314
    Type
    Article
    Language
    en
    ISSN
    0344-5704
    Collections
    All Christie Publications

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