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dc.contributor.authorBirch, Jillian Men
dc.contributor.authorMarsden, Henry Ben
dc.contributor.authorSwindell, Ricen
dc.date.accessioned2011-12-07T15:51:31Z
dc.date.available2011-12-07T15:51:31Z
dc.date.issued1980-08
dc.identifier.citationIncidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data. 1980, 42 (2):215-23 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid6252925
dc.identifier.urihttp://hdl.handle.net/10541/196278
dc.description.abstractThe Manchester Children's Tumour Registry data for the period 1954-1977 have been analysed. The overall incidence of malignant disease in children aged 0-14 years in the north-west of England is estimated to be 100 per million person-years. The most common disease group is leukaemia, which forms about one third of the total number of cases. Among solid tumours, by far the most common presenting site is the central nervous system, representing nearly a quarter of all neoplasms. Wilms' tumour, neuroblastoma and soft-tissue sarcomas comprise approximately 5%, 6.5% and 6% respectively of the total. The tumours most frequently seen in adults (e.g. carcinoma of colon, lung and breast) are extremely rare in childhood. A significant excess of males was seen in acute lymphoid leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, medulloblastoma and hepatoblastoma. A female excess was found among germ-cell tumours. During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshBrain Neoplasms
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshEngland
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshLeukemia
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshNeoplasms
dc.subject.meshNeoplasms, Connective Tissue
dc.subject.meshNeoplasms, Germ Cell and Embryonal
dc.subject.meshNeoplasms, Nerve Tissue
dc.subject.meshRhabdomyosarcoma
dc.subject.meshSex Factors
dc.titleIncidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology and Social Research, Children's Tumour Registry, Christie Hospital, Manchesteren
dc.identifier.journalBritish Journal of Canceren
dc.identifier.pmcidPMC2010396
html.description.abstractThe Manchester Children's Tumour Registry data for the period 1954-1977 have been analysed. The overall incidence of malignant disease in children aged 0-14 years in the north-west of England is estimated to be 100 per million person-years. The most common disease group is leukaemia, which forms about one third of the total number of cases. Among solid tumours, by far the most common presenting site is the central nervous system, representing nearly a quarter of all neoplasms. Wilms' tumour, neuroblastoma and soft-tissue sarcomas comprise approximately 5%, 6.5% and 6% respectively of the total. The tumours most frequently seen in adults (e.g. carcinoma of colon, lung and breast) are extremely rare in childhood. A significant excess of males was seen in acute lymphoid leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, medulloblastoma and hepatoblastoma. A female excess was found among germ-cell tumours. During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance.


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