• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Some EPR signals in tumour tissue.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Dodd, Nicholas J F
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1973-09
    
    Metadata
    Show full item record
    Abstract
    Normal and tumour tissues from rats, blood from normal and tumour bearing rats, and normal human blood were examined using the electron paramagnetic resonance (epr) technique. At low temperature a triplet epr signal, which is known to be produced by a NO-haemoprotein complex, was detected in some tumour samples and in decaying normal liver. At room temperature all of the tumour samples examined gave a doublet signal. This signal was also detected in blood but not in other normal tissues. The signal has a g value of 2·0054 ± 0·0002 and a hyperfine splitting of 1·80 ± 0·05 G and is assigned to the ascorbyl free radical. Model experiments suggest that the appearance of detectable concentrations of this radical result from a disturbance of the normal state of the ascorbic acid, dehydroascorbic acid redox system. It was verified that cell division is not responsible for the ascorbyl radical although autolysis may be involved. A possible relationship between the formation of ascorbyl radicals and other paramagnetic species in tumours is discussed.
    Citation
    Some EPR signals in tumour tissue. 1973, 28 (3):257-62 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/193473
    PubMed ID
    4355271
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Electron spin resonance study of changes during development of solid Yoshida tumour. I: Ascorbyl radical.
    • Authors: Silcock JM, Dodd NJ
    • Issue date: 1976 Nov
    • Electronic paramagnetic resonance (EPR) for the study of ascorbyl radical and lipid radicals in marine organisms.
    • Authors: González PM, Aguiar MB, Malanga G, Puntarulo S
    • Issue date: 2013 Aug
    • Soluble and particle-bound hexokinase in normal and tumour tissues of rats.
    • Authors: Sydow G
    • Issue date: 1967
    • Redox cycles of caffeic acid, alpha-tocopherol, and ascorbate: implications for protection of low-density lipoproteins against oxidation.
    • Authors: Laranjinha J, Cadenas E
    • Issue date: 1999 Jul
    • The nature of the ESR signal in lyophilized tissue and its relevance to malignancy.
    • Authors: Dodd NJ, Swartz HM
    • Issue date: 1984 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.