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    A transferable "resistance factor" from in vitro cultured MDMS-resistant Yoshida sarcoma cells.

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    Authors
    Szende, B
    Fox, M
    Fox, Brian W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1973-03
    
    Metadata
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    Abstract
    Cells of the methylene dimethanesulphonate-(MDMS)-resistant Yoshida sarcoma cell line contain a low molecular weight "resistance factor" which is present in the culture medium of these cells and may be utilized by MDMS-sensitive Yoshida sarcoma cells either by co-culturing the two cell lines or by culturing the MDMS-sensitive Yoshida cells in a medium containing 20% used medium of MDMS-resistant Yoshida cells or in the presence of dialysed medium from resistant cells. The "resistance factor" does not inactivate the drug itself or its metabolites, and it has no influence on the sensitivity of the cells if added after MDMS treatment. Twenty-four hours seems to be enough time for the transfer of the resistance factor, but its effect on whole populations decreases within 24 hours of ceasing the supply. The relationship between these findings and the known phenomena of metabolic co-operation are discussed.
    Citation
    A transferable "resistance factor" from in vitro cultured MDMS-resistant Yoshida sarcoma cells. 1973, 27 (3):245-52 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/193472
    PubMed ID
    4735113
    PubMed Central ID
    PMC2008780
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008780/?tool=pubmed
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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