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    Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities.

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    Authors
    O'Connor, Peter J
    Capps, M J
    Craig, A W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1973-02
    
    Metadata
    Show full item record
    Abstract
    The reaction of the hepatocarcinogen N,N-dimethylnitrosamine has been compared with that of methyl methanesulphonate, a methylating agent which is not a liver carcinogen. Consistent differences have been observed in the reaction of rat liver DNA in vivo with these agents; O(6)-alkylation and the production of unidentified acid-labile products were distinctive features of the reaction with the carcinogenic nitroso compound but were undetectable or in low yield, respectively, after reaction with the alkyl sulphonate. Evidence has been obtained for the excision of these reaction products in animals treated with the hepatocarcinogen and the significance of their relative stabilities is discussed.
    Citation
    Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities. 1973, 27 (2):153-66 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/193468
    PubMed ID
    4694387
    PubMed Central ID
    PMC2008841
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008841/?tool=pubmed
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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