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    Cell surface antigenic changes induced in normal adult rat liver cells by carcinogen treatment in vitro.

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    Authors
    Iype, P T
    Baldwin, R
    Glaves, D
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1973-02
    
    Metadata
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    Abstract
    Normal rat liver cell lines treated with the chemical carcinogen N-methyl-N-nitrosourea (MNU) elicited antibody production (detected by membrane immunofluorescence test in vitro) when injected into a highly inbred strain of rats from which the liver cells were originally isolated. In contrast, the control cells which were untreated did not evoke humoral antibodies. Antisera raised against the MNU-treated cells reacted not only with the immunizing cells, but also with 3'-methyl-4-dimethyl aminoazobenzene and 3-methylcholanthrene-treated cells. However, this antiserum failed to react with cells treated with either aflatoxin or N-acetoxy-2-acetyl-aminofluorene. Embryonic antigens were found to be absent from the normal adult liver cell line. Preliminary results indicated that none could be detected on carcinogen-treated cells either.
    Citation
    Cell surface antigenic changes induced in normal adult rat liver cells by carcinogen treatment in vitro. 1973, 27 (2):128-33 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/193101
    PubMed ID
    4571664
    PubMed Central ID
    PMC2008848
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008848/?tool=pubmed
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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