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dc.contributor.authorAl-Barwari, Shlemon E
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2011-11-25T15:20:48Z
dc.date.available2011-11-25T15:20:48Z
dc.date.issued1976-09
dc.identifier.citationRegeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. 1976, 30 (3):201-16 Int J Radiat Biol Relat Stud Phys Chem Meden
dc.identifier.issn0020-7616
dc.identifier.pmid1086835
dc.identifier.doi10.1080/09553007614550981
dc.identifier.urihttp://hdl.handle.net/10541/190837
dc.description.abstractA microcolony technique is described for measuring epidermal cell survival 3 days after whole-body X-irradiation. This assay provides a cell D0 value of 233 +/- 11 rad and a zero-dose extrapolate of 1-23 x 10(4) cells/cm2 for mice irradiated in oxygen 20 hours after hair plucking. The microcolony cellularity had an apparent doubling-time of 25 hours which may be an upper limit at least for some clones. The clones appeared to fragment continually and form new daughter clones, suggesting that few would form macroscopic nodules. Many of the clones were also apparently associated with hair follicles.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred DBA
dc.subject.meshRegeneration
dc.subject.meshSkin
dc.subject.meshX-Rays
dc.titleRegeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicineen
html.description.abstractA microcolony technique is described for measuring epidermal cell survival 3 days after whole-body X-irradiation. This assay provides a cell D0 value of 233 +/- 11 rad and a zero-dose extrapolate of 1-23 x 10(4) cells/cm2 for mice irradiated in oxygen 20 hours after hair plucking. The microcolony cellularity had an apparent doubling-time of 25 hours which may be an upper limit at least for some clones. The clones appeared to fragment continually and form new daughter clones, suggesting that few would form macroscopic nodules. Many of the clones were also apparently associated with hair follicles.


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