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    Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells.

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    Authors
    Al-Barwari, Shlemon E
    Potten, Christopher S
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1976-09
    
    Metadata
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    Abstract
    A microcolony technique is described for measuring epidermal cell survival 3 days after whole-body X-irradiation. This assay provides a cell D0 value of 233 +/- 11 rad and a zero-dose extrapolate of 1-23 x 10(4) cells/cm2 for mice irradiated in oxygen 20 hours after hair plucking. The microcolony cellularity had an apparent doubling-time of 25 hours which may be an upper limit at least for some clones. The clones appeared to fragment continually and form new daughter clones, suggesting that few would form macroscopic nodules. Many of the clones were also apparently associated with hair follicles.
    Citation
    Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. 1976, 30 (3):201-16 Int J Radiat Biol Relat Stud Phys Chem Med
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/190837
    DOI
    10.1080/09553007614550981
    PubMed ID
    1086835
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553007614550981
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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