Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells.
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
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AbstractA microcolony technique is described for measuring epidermal cell survival 3 days after whole-body X-irradiation. This assay provides a cell D0 value of 233 +/- 11 rad and a zero-dose extrapolate of 1-23 x 10(4) cells/cm2 for mice irradiated in oxygen 20 hours after hair plucking. The microcolony cellularity had an apparent doubling-time of 25 hours which may be an upper limit at least for some clones. The clones appeared to fragment continually and form new daughter clones, suggesting that few would form macroscopic nodules. Many of the clones were also apparently associated with hair follicles.
CitationRegeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. 1976, 30 (3):201-16 Int J Radiat Biol Relat Stud Phys Chem Med
JournalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine