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    The sensitivity of HeLa and Chinese hamster (ovary) cells to methylene dimethane sulphonate.

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    Authors
    Nias, A H
    Fox, Brian W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX Great Britain
    Issue Date
    1976-07
    
    Metadata
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    Abstract
    HeLa and Chinese hamster (ovary) cells were exposed in vitro to methylene dimethanesulphonate (MDMS) and their survival of colony-forming ability was assayed in monolayer culture. Asynchronous cultures were exposed to the drug for the whole culture period but cell survival was complicated by the toxicity of formaldehyde which is a final breakdown product of the drug. A short treatment schedule of 15 min within the hydrolytic half life of the agent was therefore employed and the response of synchronous cultures of HeLa cells was then assayed throughout the course of the cells cycle. Cells were most sensitive at the beginning of the DNA synthetic phase (early-S) and most resistant at the end (late-S).
    Citation
    The sensitivity of HeLa and Chinese hamster (ovary) cells to methylene dimethane sulphonate. 1976, 14 (1-2):93-9 Chem Biol Interact
    Journal
    Chemico-Biological Interactions
    URI
    http://hdl.handle.net/10541/190830
    PubMed ID
    182391
    Type
    Article
    Language
    en
    ISSN
    0009-2797
    10.1016/0009-2797(76)90027-2
    Collections
    All Paterson Institute for Cancer Research

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