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    The effect of dibromodulcitol on resting and dividing lymphoid cells.

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    Authors
    Jeney, A
    Fox, Brian W
    Garrett, J V
    Fox, Margaret
    Holland, J
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX Great Britain
    Issue Date
    1976-12
    
    Metadata
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    Abstract
    The effect of dibromodulcitol (DBD) on the incorporation of labelled precursors into DNA and RNA fractions of PHA-stimulated human lymphocytes and of P388F lymphoma cells at various stages of their growth was studied. Both cell systems showed sensitivity to the drug within the concentration rage of 1-10 mug/ml. When DBD was added before phytohaemagglutinin (PHA), h.han RNA. In contrast, by adding DBD after PHA, RNA labelling was much more inhibited than DNA. In the latter case, the decrease in DNA labelling occurred only 24 h after drug treatment whereas RNA labelling was decreased 1 h after treatment. Levels of DBD which normally produced 30% inhibition in plating efficiency of P388F lymphoma cells affected uridine-5-T incorporation to a different extent at different stages of growth of the culture. Enhanced RNA labelling occurred in early exponential stage while at later stages of growth, RNA synthesis was depressed.
    Citation
    The effect of dibromodulcitol on resting and dividing lymphoid cells. 1976, 15 (4):299-307 Chem Biol Interact
    Journal
    Chemico-Biological Interactions
    URI
    http://hdl.handle.net/10541/190812
    DOI
    1016/0009-2797(76)90135-6
    PubMed ID
    1009628
    Type
    Article
    Language
    en
    ISSN
    0009-2797
    ae974a485f413a2113503eed53cd6c53
    1016/0009-2797(76)90135-6
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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