Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines.
Affiliation
Cancer Research Campaign Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester M20 9BX, EnglandIssue Date
1980-12
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Three dimensional gels of native type I collagen fibres have been used as a substratum for the growth and migration of Chinese hamster ovary cells (fibroblastoid cell line) and RPMI-3460 melanoma cells (tumorigenic cell line from Syrian hamster). Quantitative data concerning the migration of these cells from the gel surface into the 3-dimensional collagen gel matrix have been obtained. The migration of both cell types into the collagen gel matrix is not accompanied by the degradation of collagen fibres. The possible implications of these observations for tumour cell invasion in vivo are discussed.Citation
Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines. 1980, 46:171-86 J Cell SciJournal
Journal of Cell SciencePubMed ID
7194877Type
ArticleLanguage
enISSN
0021-9533Collections
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