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    Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines.

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    Authors
    Schor, Seth L
    Allen, Terence D
    Harrison, Christine J
    Affiliation
    Cancer Research Campaign Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester M20 9BX, England
    Issue Date
    1980-12
    
    Metadata
    Show full item record
    Abstract
    Three dimensional gels of native type I collagen fibres have been used as a substratum for the growth and migration of Chinese hamster ovary cells (fibroblastoid cell line) and RPMI-3460 melanoma cells (tumorigenic cell line from Syrian hamster). Quantitative data concerning the migration of these cells from the gel surface into the 3-dimensional collagen gel matrix have been obtained. The migration of both cell types into the collagen gel matrix is not accompanied by the degradation of collagen fibres. The possible implications of these observations for tumour cell invasion in vivo are discussed.
    Citation
    Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines. 1980, 46:171-86 J Cell Sci
    Journal
    Journal of Cell Science
    URI
    http://hdl.handle.net/10541/189410
    PubMed ID
    7194877
    Type
    Article
    Language
    en
    ISSN
    0021-9533
    Collections
    All Paterson Institute for Cancer Research

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