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    The effect of prostaglandin E1 on hemopoiesis in long-term bone marrow cultures.

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    Authors
    Motomura, S
    Dexter, T Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1980-03
    
    Metadata
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    Abstract
    The effect of prostaglandin E1 (PGE1) on the proliferation and differentiation of hemopoietic stem cells has been studied in a long-term bone marrow liquid culture system. In cultures supplemented with PGE1, there was a dose dependent decrease in both CFUS and CFUc. (CSA levels rose dose dependently, with a concomitant increase in mature granulocyte production. Macrophage production was suppressed.) After cessation of PGE1 treatment, CFUS and CFUc returned gradually to the control values and CSA was not detectable. There was no significant effect on hemopoiesis in cultures supplemented with 10(-8) M or less concentrations.
    Citation
    The effect of prostaglandin E1 on hemopoiesis in long-term bone marrow cultures. 1980, 8 (3):298-303 Exp Hematol
    Journal
    Experimental Hematology
    URI
    http://hdl.handle.net/10541/189393
    PubMed ID
    6970134
    Type
    Article
    Language
    en
    ISSN
    0301-472X
    Collections
    All Paterson Institute for Cancer Research

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