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    Hypothyroidism following childhood cancer therapy-an under diagnosed complication.

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    Authors
    Brabant, Georg E
    Toogood, Andy
    Shalet, Stephen M
    Frobisher, Clare
    Lancashire, Emma R
    Reulen, Raoul C
    Winter, David L
    Hawkins, Michael M
    Affiliation
    Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, United Kingdom. georg.brabant@manchester.ac.uk.
    Issue Date
    2011-03-28
    
    Metadata
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    Abstract
    To determine the prevalence of hypothyroidism amongst most adult survivors of childhood cancer in Britain using the British Childhood Cancer Survivor Study (BCCSS). The BCCSS is a population based cohort of individuals diagnosed with childhood cancer between 1940 and 1991 and who survived at least 5 years from diagnosis (n = 17,981). 10483, 71% of those survivors aged at least 16 years, returned a completed questionnaire, which asked if hypothyroidism had been diagnosed. Of the whole cohort, 7.7% reported hypothyroidism with the highest risk among patients treated for Hodgkin's disease (HD) (19.9%), CNS neoplasms (15.3%), Non-Hodgkin's lymphoma (6.2%) and leukaemia (5.2%). Survivors were more likely to develop hypothyroidism if they had received radiotherapy for HD (p = 0.0001) or a CNS neoplasm (p < 0.00005) but not leukaemia (p = 0.3). In these three patient groups, the frequency of hypothyroidism was similar in men and women. Survivors of irradiated CNS tumours reported a prevalence of hypothyroidism, which was substantially lower if discharged to primary care compared with being on hospital follow-up and which declined substantially with increased follow-up in both primary care (p = 0.004) and hospital follow-up (p = 0.023) settings. Hypothyroidism is a common finding amongst adult survivors of childhood malignancy. The substantial differences in reported hypothyroidism prevalence after irradiated CNS neoplasms suggests substantial under-diagnosis, which increased with increased follow-up, and which increased among those followed-up in primary care compared with hospital settings.
    Citation
    Hypothyroidism following childhood cancer therapy-an under diagnosed complication. 2011,130(5):1145-50 Int J Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/189131
    DOI
    10.1002/ijc.26086
    PubMed ID
    21445977
    Type
    Article
    Language
    en
    ISSN
    1097-0215
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.26086
    Scopus Count
    Collections
    All Christie Publications
    Endocrinology

    entitlement

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