Authors
Dowsett, MitchSalter, Janine
Zabaglo, Lila
Mallon, Elizabeth A
Howell, Anthony
Buzdar, Aman
Forbes, John F
Pineda, S
Cuzick, Jack
Affiliation
Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London SW36JJ, UK.Issue Date
2011-07
Metadata
Show full item recordAbstract
Estrogen receptor (ER) positive primary breast cancers have a wide range of clinical outcomes. Prediction of the likely course of the disease aids treatment decision-making. In the translational arm of the ATAC (anastrozole or tamoxifen alone or combined) trial (TransATAC) we have assessed individual and multiparameter biomarkers for their prediction of overall and distant recurrence. None of the biomarkers identified differential benefit for anastrozole versus tamoxifen. Each of ER, PgR, HER2 and Ki67 was associated with risk of recurrence. A combination of these to create a single predictor IHC4 was as informative as the 21-gene recurrence score (RS). Integration of each of these molecular profiles with classical clinicopathologic variables provided the most accurate prediction of outcome.Citation
Predictive algorithms for adjuvant therapy: TransATAC. 2011, 76 (8):777-80 SteroidsJournal
SteroidsDOI
10.1016/j.steroids.2011.02.032PubMed ID
21470560Type
ArticleLanguage
enISSN
1878-5867ae974a485f413a2113503eed53cd6c53
10.1016/j.steroids.2011.02.032
Scopus Count
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