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    Sensitization of hypoxic normal tissue.

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    Authors
    Hendry, Jolyon H
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1978-06
    
    Metadata
    Show full item record
    Abstract
    The radiosensitization by misonidazole of three normal tissues in the unanaeshtetized mouse (femoral marrow, intestinal crypts and the target tissue for tail necrosis) has been studied. At 1 mg/g body weight, no sensitization was observed for the former two tissues, and no cytotoxicity for marrow was demonstrated. Sensitization of fully anoxic marrow or tail shown, by a factor of 1.8--1.9, in comparison with normal tails (factor 1.5). Clamping experiments revealed the homogenous nature of the natural hypoxia in the tissue responsible for tail necrosis, and an effective increase in the oxygenation was seen at Day 7 after a large priming dose.
    Citation
    Sensitization of hypoxic normal tissue. 1978, 3:232-4 Br. J. Cancer Suppl.
    Journal
    British Journal of Cancer. Supplement
    URI
    http://hdl.handle.net/10541/146371
    PubMed ID
    277235
    PubMed Central ID
    PMC2149423
    Type
    Article
    Language
    en
    ISSN
    0306-9443
    Collections
    All Paterson Institute for Cancer Research

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