Show simple item record

dc.contributor.authorVose, Brent M
dc.contributor.authorVánky, F
dc.contributor.authorFopp, M
dc.contributor.authorKlein, E
dc.date.accessioned2011-10-14T13:23:30Z
dc.date.available2011-10-14T13:23:30Z
dc.date.issued1978-09
dc.identifier.citationRestricted autologous lymphocytotoxicity in lung neoplasia. 1978, 38 (3):375-81 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid81674
dc.identifier.urihttp://hdl.handle.net/10541/145361
dc.description.abstractBlood lymphocytes from 47 patients with lung carcinoma have been tested for cytotoxicity against cells isolated from the autologous tumour. Significant cytotoxic potential was found in 15 cases. The effectors were also tested against allogeneic tumour targets from lung and other sites. Reactions were only rarely detected (2/32 positive against lung and 1/13 positive against non-lung cells). The restriction of cytotoxicity to the autologous combination was also apparent in in vitro-generated effectors. Blood lymphocytes were co-cultivated with autologous tumour and subsequently tested against autologous or allogeneic targets. Cytotoxicity was found in 13/17 lung tumours against autologous tumour, with no reactions recorded against allogeneic tumour targets, but one case positive against the K562 cell line. These data suggest either the expression of individually distinct antigens on human pulmonary neoplasms, or the requirement for histocompatibility between target and effector in cytotoxicity reactions in man, and therefore differ from previously described patterns of lymphocytotoxicity against human tumours.
dc.language.isoenen
dc.subject.meshCell Line
dc.subject.meshCells, Cultured
dc.subject.meshCytotoxicity, Immunologic
dc.subject.meshEpitopes
dc.subject.meshHistocompatibility
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshLymphocytes
dc.titleRestricted autologous lymphocytotoxicity in lung neoplasia.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalBritish Journal of Canceren
dc.identifier.pmcidPMC2009731
html.description.abstractBlood lymphocytes from 47 patients with lung carcinoma have been tested for cytotoxicity against cells isolated from the autologous tumour. Significant cytotoxic potential was found in 15 cases. The effectors were also tested against allogeneic tumour targets from lung and other sites. Reactions were only rarely detected (2/32 positive against lung and 1/13 positive against non-lung cells). The restriction of cytotoxicity to the autologous combination was also apparent in in vitro-generated effectors. Blood lymphocytes were co-cultivated with autologous tumour and subsequently tested against autologous or allogeneic targets. Cytotoxicity was found in 13/17 lung tumours against autologous tumour, with no reactions recorded against allogeneic tumour targets, but one case positive against the K562 cell line. These data suggest either the expression of individually distinct antigens on human pulmonary neoplasms, or the requirement for histocompatibility between target and effector in cytotoxicity reactions in man, and therefore differ from previously described patterns of lymphocytotoxicity against human tumours.


This item appears in the following Collection(s)

Show simple item record