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    Bone marrow culture studies in refractory cytopenia and 'smouldering leukaemia'.

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    Authors
    Milner, G
    Testa, Nydia G
    Geary, C G
    Dexter, T Michael
    Muldal, S
    MacIver, J
    Lajtha, L G
    Issue Date
    1977-02
    
    Metadata
    Show full item record
    Abstract
    As an adjunct to conventional haematological and cytogenetic data, 22 cases of refractory cytopenia, and five with chronic myelomonocytic leukaemia, (CMML) were studied by bone marrow culture. Cultures from II such patients without an excess of marrow myeloblasts usually showed low, or undetectable, numbers of cells capable of giving rise to colonies of granulocytes and/or macrophages (CFUc) but near-normal numbers of cluster-forming cells and cells capable of forming erythroid colonies (CFUE). Those with similar blood pictures, but in whom the marrow contained a slight excess of myeloblasts (II cases), showed a more profound defect in growth patterns: low or undetectable numbers of CFUC, clusters and CFUE, results similar to those found in acute myeloblastic leukaemia, into which three of this group evolved. The patients with CMML gave comparatively normal CFUC, cluster and CFUE growth patterns.
    Citation
    Bone marrow culture studies in refractory cytopenia and 'smouldering leukaemia'. 1977, 35 (2):251-61 Br J Haematol
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/144872
    DOI
    10.1111/j.1365-2141.1977.tb00582.x
    PubMed ID
    265733
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.1977.tb00582.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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