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dc.contributor.authorPortman, E
dc.contributor.authorFox, Brian W
dc.contributor.authorBoyle, John M
dc.date.accessioned2011-10-11T13:54:48Z
dc.date.available2011-10-11T13:54:48Z
dc.date.issued1977-08
dc.identifier.citationCharacteristics of dimer formation, excision and DNA strand growth in Yoshida sensitive and resistant cells after ultraviolet irradiation. 1977, 32 (2):165-74 Int J Radiat Biol Relat Stud Phys Chem Meden
dc.identifier.issn0020-7616
dc.identifier.pmid197037
dc.identifier.urihttp://hdl.handle.net/10541/144870
dc.description.abstractThe sedimentation properties of the nascent DNA of Yoshida sarcoma cells, sensitive and resistant to methylene dimethane sulphonate and cross-resistant to U.V. light, have been studied after irradiation with U.V. light at 11 and 22J/m2. It has been shown that the DNA formed immediately after irradiation with 11J/m2 is some eight to nine times longer than the calculated inter--dimer distance in both cell-lines. Differences were, however, observed between the two cell-lines, in that the absence of excision of dimers in the sensitive cells was accompanied by the formation of a DNA component of low molecular weight, whereas excision in the resistant line was not so accompanied. There are some similarities between the Yoshida tumour line sensitive to methylene dimethane sulphonate and the U.V.-sensitive line of Xeroderma pigmentosum.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCells, Cultured
dc.subject.meshDNA Repair
dc.subject.meshDNA, Neoplasm
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshMesylates
dc.subject.meshPyrimidine Dimers
dc.subject.meshSarcoma, Yoshida
dc.subject.meshUltraviolet Rays
dc.titleCharacteristics of dimer formation, excision and DNA strand growth in Yoshida sensitive and resistant cells after ultraviolet irradiation.en
dc.typeArticleen
dc.identifier.journalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicineen
html.description.abstractThe sedimentation properties of the nascent DNA of Yoshida sarcoma cells, sensitive and resistant to methylene dimethane sulphonate and cross-resistant to U.V. light, have been studied after irradiation with U.V. light at 11 and 22J/m2. It has been shown that the DNA formed immediately after irradiation with 11J/m2 is some eight to nine times longer than the calculated inter--dimer distance in both cell-lines. Differences were, however, observed between the two cell-lines, in that the absence of excision of dimers in the sensitive cells was accompanied by the formation of a DNA component of low molecular weight, whereas excision in the resistant line was not so accompanied. There are some similarities between the Yoshida tumour line sensitive to methylene dimethane sulphonate and the U.V.-sensitive line of Xeroderma pigmentosum.


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