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    Circadian rhythms of presumptive stem cells in three different epithelia of the mouse.

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    Authors
    Potten, Christopher S
    Al-Barwari, S
    Hume, W J
    Searle, J
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1977-11
    
    Metadata
    Show full item record
    Abstract
    Variation in the percentage of labelled cells (LI), mitoses (MI) and apoptosis (AI: i.e. shrinkage necrosis) have been studied throughout a 24 hr period (40 min after labelling with 3H-TdR) for tongue epithelium, epidermis and intestinal epithelium in the mouse. A room with reversed light cycle was used to obtain data for half of the 24 hr period. All three tissues showed marked variations in LI with peak values between 24.00 and 03.00 hours. In the intestine a maximum value for MI was observed 3-6 hr after that for LI and with a maximum value for AI slightly later. In all three epithelia the circadian rhythm was most striking in cells at positions which can be correlated with presumptive stem cell activity; e.g. in the crypts the labelling and mitotic peaks reflecting a circadian rhythm were most clearly distinguishable at the basal part of the crypts. These observations are discussed in relation to the validity of various proliferative models.
    Citation
    Circadian rhythms of presumptive stem cells in three different epithelia of the mouse. 1977, 10 (6):557-68 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/144163
    PubMed ID
    922804
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    Collections
    All Paterson Institute for Cancer Research

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