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    The effect of adherent and phagocytic cells on human lymphocyte PHA responsiveness.

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    Authors
    Potter, M R
    Moore, Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1977-01
    
    Metadata
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    Abstract
    The effect of small numbers of adherent and phagocytic cells on the human peripheral blood lymphocyte response to PHA was examined by depleting these cells from lymphocyte preparations. Lymphocyte preparations obtained by centrifugation on Ficoll--Triosil, which contained on average 85% lymphocytes, responded well to PHA. Depletion of cells adhering to nylon fibre, giving a population containing on average 95% lymphocytes, resulted in a considerably reduced response. Depletion of cells that adhered to plastic or ingested iron powder to give populations containing on average 90% lymphocytes, also reduced the PHA response, but to a lesser extent. Reduction in PHA responsiveness correlated with increasing lymphocyte purity. The responsiveness of nylon-column-filtered cells could be restored by adding a small number of cells from a monocyte-rich population.
    Citation
    The effect of adherent and phagocytic cells on human lymphocyte PHA responsiveness. 1977, 27 (1):159-64 Clin Exp Immunol
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/10541/143456
    PubMed ID
    300303
    Type
    Article
    Language
    en
    ISSN
    0009-9104
    Collections
    All Paterson Institute for Cancer Research

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