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    Studies on nucleic acids in lymphocytes of chronic lymphocytic leukaemia.

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    Authors
    Billington, R
    Itzhaki, Ruth F
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1975
    
    Metadata
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    Abstract
    The resting lymphocytes of patients with chronic lymphocytic leukaemia (CLL) contain the same amount of RNA as do those of normal individuals, and in terms of different molecular species, as analyzed by polyacrylamide gels, there is very little to distinguish the leukaemic cells. However, a relatively large amount of low molecular weight RNA, similar to the SnRNA found in several other tissues, is present in the CLL cells. The products of transcription of the leukaemic cell nucleus have been studied by the incorporation of labelled uridine and methionine. The leukaemic lymphocytes show a build-up and apparent delay in processing of ribosomal RNA precursor, when compared to normals, but studies of methylation reveal that the production of mature ribosomal RNA occurs at a normal rate. The nature of the stable high molecular weight material produced is now being studied. The production of proteins on the ribosome of CLL cells seems likely to be faulty, as evidenced by the deficiency of active ribosomes in the leukaemic cells. Studies with selective inhibitors will show whether this is due to some fault in transcription of messenger RNA.
    Citation
    Studies on nucleic acids in lymphocytes of chronic lymphocytic leukaemia. 1975, 54 (4):242-7 Acta Haematol.
    Journal
    Acta Haematologica
    URI
    http://hdl.handle.net/10541/140631
    DOI
    10.1159/000208081
    PubMed ID
    811038
    Type
    Article
    Language
    en
    ISSN
    0001-5792
    ae974a485f413a2113503eed53cd6c53
    10.1159/000208081
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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