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    The time course of DNA repair following methyl nitro-nitrosoguanidine (MNNG) treatment of P388F lymphoma cells in culture. I. Alkali dissociable DNA lesions and their restitution.

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    Authors
    Nikaido, O
    Fox, Brian W
    Issue Date
    1976-07
    
    Metadata
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    Abstract
    The pattern of formation and rejoining of P388F cell DNA single strand breaks revealed by alkaline sedimentation centrifugation studies following treatment with methyl nitro-nitrosoguanidine (MNNG) has been studied. Three periods of single strand break formation have been recognised, an initial period during the first 4 h where breaks are rapidly formed and rejoined, a second (medial) time range of 10-15 h following treatment and a final stage where the formation of breaks appears to be related to cell killing processes. The initial phase is considered to be due to the production and repair of X-ray like DNA lesions whereas those of the medial time range are more comparable to the enzymatic processes associated with the repair of ultraviolet light-induced damage.
    Citation
    The time course of DNA repair following methyl nitro-nitrosoguanidine (MNNG) treatment of P388F lymphoma cells in culture. I. Alkali dissociable DNA lesions and their restitution. 1976, 14 (1-2):37-45 Chem Biol Interact
    Journal
    Chemico-Biological Interactions
    URI
    http://hdl.handle.net/10541/140470
    DOI
    10.1016/0009-2797(76)90022-3
    PubMed ID
    954139
    Type
    Article
    Language
    en
    ISSN
    0009-2797
    ae974a485f413a2113503eed53cd6c53
    10.1016/0009-2797(76)90022-3
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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