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    Inhibitor of stem cell proliferation in normal bone marrow.

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    Authors
    Lord, Brian I
    Mori, K J
    Wright, Eric G
    Lajtha, L G
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1976-11
    
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    Abstract
    A saline extract from normal bone marrow cells having a molecular weight in the range 50000-1000000 daltons has been found to protect rapidly proliferating haemopoietic spleen colony forming cells (CFUs) from the lethal effects of large doses of tritiated thymidine. This extract is non-toxic to the cells. It is not found in regenerating marrow where the CFUs population is rapidly proliferating. Its effect appears to be specific for the CFUs since it has no effect on the proliferation of its close descendant, the granulocytic precursor cell (CFUc), and no effect on the average cytoplasmic structuredness of the whole bone marrow cell population. The active material is probably protein since it is degraded by trypsin.
    Citation
    Inhibitor of stem cell proliferation in normal bone marrow. 1976, 34 (3):441-5 Br J Haematol
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/140114
    PubMed ID
    990183
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    Collections
    All Paterson Institute for Cancer Research

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