AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
MetadataShow full item record
AbstractA saline extract from normal bone marrow cells having a molecular weight in the range 50000-1000000 daltons has been found to protect rapidly proliferating haemopoietic spleen colony forming cells (CFUs) from the lethal effects of large doses of tritiated thymidine. This extract is non-toxic to the cells. It is not found in regenerating marrow where the CFUs population is rapidly proliferating. Its effect appears to be specific for the CFUs since it has no effect on the proliferation of its close descendant, the granulocytic precursor cell (CFUc), and no effect on the average cytoplasmic structuredness of the whole bone marrow cell population. The active material is probably protein since it is degraded by trypsin.
CitationInhibitor of stem cell proliferation in normal bone marrow. 1976, 34 (3):441-5 Br J Haematol
JournalBritish Journal of Haematology
- The relative spatial distributions of CFUs and CFUc in the normal mouse femur.
- Authors: Lord BI, Testa NG, Hendry JH
- Issue date: 1975 Jul
- A stimulator of stem cell proliferation in regenerating bone marrow.
- Authors: Lord BI, Mori KJ, Wright EG
- Issue date: 1977 Jul
- Hemopoietic activity in bone marrow chimeras prepared with total lymphoid irradiation (TLI).
- Authors: Slavin S, Seidel HJ
- Issue date: 1982 Feb
- A preliminary report: preparations containing Interleukin-3 (IL-3) promote proliferation of multipotential stem cells (CFUs) in the mouse.
- Authors: Garland JM, Crompton S
- Issue date: 1983 Sep
- Radiation sensitivity and cycling status of mouse bone marrow prothymocytes and day 8 colony forming units spleen (CFUs).
- Authors: Boersma WJ
- Issue date: 1983 Nov