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dc.contributor.authorKrizsa, F
dc.contributor.authorKelemen, E
dc.contributor.authorCserhati, I
dc.contributor.authorLajtha, L G
dc.date.accessioned2011-08-11T13:02:07Z
dc.date.available2011-08-11T13:02:07Z
dc.date.issued1977-06
dc.identifier.citationSpecific thrombopoietic inhibition by syngeneic platelet homogenates. 1977, 27 (4):145-8 Biomedicineen
dc.identifier.issn0300-0893
dc.identifier.pmid890022
dc.identifier.urihttp://hdl.handle.net/10541/139522
dc.description.abstractInjections of 1 to 2.5 X 10(8) syngeneic, uninjured platelets did not diminish the circulating platelet count nor the bone marrow megakaryocyte content in mice, and did not influence the incorporation of 75selenomethionine into circulating platelets. However, platelet homogenates, prepared by repeated freezing and thawing of identical amounts of syngeneic paltelets induced a dose-dependent thrombocytopenia along with a diminution on bone marrow megakaryocyte content, and a decrease in 75 selenomethionine incorporation. Other circulating blood cell counts were not diminished after platelet homogenates, and three intravenous doses of homogenates prepared from 0.7 to 1 X 10(5) syngeneic buffy coat cells failed to influence circulating platelet count or 75 selenomethionine incorporation.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshBlood Cell Count
dc.subject.meshBlood Platelets
dc.subject.meshBlood Transfusion
dc.subject.meshBone Marrow Examination
dc.subject.meshCell Count
dc.subject.meshInjections, Intravenous
dc.subject.meshMale
dc.subject.meshMegakaryocytes
dc.subject.meshMice
dc.subject.meshMice, Inbred CBA
dc.subject.meshMice, Inbred Strains
dc.subject.meshPlatelet Transfusion
dc.subject.meshSelenomethionine
dc.subject.meshThrombocytopenia
dc.subject.meshTransplantation, Isogeneic
dc.titleSpecific thrombopoietic inhibition by syngeneic platelet homogenates.en
dc.typeArticleen
dc.identifier.journalBiomedicineen
html.description.abstractInjections of 1 to 2.5 X 10(8) syngeneic, uninjured platelets did not diminish the circulating platelet count nor the bone marrow megakaryocyte content in mice, and did not influence the incorporation of 75selenomethionine into circulating platelets. However, platelet homogenates, prepared by repeated freezing and thawing of identical amounts of syngeneic paltelets induced a dose-dependent thrombocytopenia along with a diminution on bone marrow megakaryocyte content, and a decrease in 75 selenomethionine incorporation. Other circulating blood cell counts were not diminished after platelet homogenates, and three intravenous doses of homogenates prepared from 0.7 to 1 X 10(5) syngeneic buffy coat cells failed to influence circulating platelet count or 75 selenomethionine incorporation.


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