Re-irradiation of rat tails to necrosis at six months after treatment with a "tolerance" dose of x rays or neutrons.
dc.contributor.author | Hendry, Jolyon H | |
dc.contributor.author | Rosenberg, I | |
dc.contributor.author | Greene, D | |
dc.contributor.author | Stewart, J | |
dc.date.accessioned | 2011-08-11T12:46:54Z | |
dc.date.available | 2011-08-11T12:46:54Z | |
dc.date.issued | 1977-08 | |
dc.identifier.citation | Re-irradiation of rat tails to necrosis at six months after treatment with a "tolerance" dose of x rays or neutrons. 1977, 50 (596):567-72 Br J Radiol | en |
dc.identifier.issn | 0007-1285 | |
dc.identifier.pmid | 890231 | |
dc.identifier.uri | http://hdl.handle.net/10541/139519 | |
dc.description.abstract | Rat tails were re-irradiated to necrosis levels at about six months after various fractionated treatments with 290 kV X rays or 14 MeV neutrons. The X ray dose required to produce necrosis in half of a group of tails (ND50), which had been heavily X-irradiated six months before, was 91+/-4% of the ND50 for aged controls. After prior neutron-irradiation, however, this value was 87+/-4% (neutrons in second treatment) or 75+/-5% (X rays in second course). The "effective" oxygenation of mouse tails at this time after X-irradiation was similar to that of controls; thus these percentage dose values indicate the remarkable tolerance of this organized tissue to a second course of X-irradiation, and the presence of more residual injury in neutron-irradiated tissues. | |
dc.language.iso | en | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Female | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Necrosis | |
dc.subject.mesh | Neutrons | |
dc.subject.mesh | Radiation Dosage | |
dc.subject.mesh | Radiation Injuries, Experimental | |
dc.subject.mesh | Radiation Tolerance | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Tail | |
dc.subject.mesh | Time Factors | |
dc.subject.mesh | X-Rays | |
dc.title | Re-irradiation of rat tails to necrosis at six months after treatment with a "tolerance" dose of x rays or neutrons. | en |
dc.type | Article | en |
dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester | en |
dc.identifier.journal | The British Journal of Radiology | en |
html.description.abstract | Rat tails were re-irradiated to necrosis levels at about six months after various fractionated treatments with 290 kV X rays or 14 MeV neutrons. The X ray dose required to produce necrosis in half of a group of tails (ND50), which had been heavily X-irradiated six months before, was 91+/-4% of the ND50 for aged controls. After prior neutron-irradiation, however, this value was 87+/-4% (neutrons in second treatment) or 75+/-5% (X rays in second course). The "effective" oxygenation of mouse tails at this time after X-irradiation was similar to that of controls; thus these percentage dose values indicate the remarkable tolerance of this organized tissue to a second course of X-irradiation, and the presence of more residual injury in neutron-irradiated tissues. |