Show simple item record

dc.contributor.authorLord, Brian I
dc.contributor.authorTesta, Nydia G
dc.contributor.authorWright, Eric G
dc.contributor.authorBanerjee, R
dc.date.accessioned2011-08-08T11:16:16Z
dc.date.available2011-08-08T11:16:16Z
dc.date.issued1977-05
dc.identifier.citationLack of effect of a granulocyte proliferation inhibitor or their committed precursor cells. 1977, 26 (3):163-9 Biomedicineen
dc.identifier.issn0300-0893
dc.identifier.pmid890011
dc.identifier.urihttp://hdl.handle.net/10541/139097
dc.description.abstractUsing the agar culture technique, we have measured the effect of granulocyte extracts GCE (and of erythrocyte-RCE and lymph node extracts-LNE) on the growth and proliferation of the committed granulocytic precursor cells, CFU-C. In addition we have determined their effects on the proliferation of the developing colony cells and on the ultimate cell production in the colonies. The results show that GCE has no effect on the growth or proliferative activity on the CFU-C. It does, however, reduce both the autoradiographic labelling indices of the developing colony cells and the net colony cellularities, acting as a cell cycle modulator. These are effects specific to the GCE since at the dose levels used, neither RCE nor LNE affected these measurements.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Division
dc.subject.meshCells, Cultured
dc.subject.meshClone Cells
dc.subject.meshGranulocytes
dc.subject.meshHematopoiesis
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshLeukocytes
dc.subject.meshMice
dc.subject.meshRats
dc.titleLack of effect of a granulocyte proliferation inhibitor or their committed precursor cells.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalBiomedicineen
html.description.abstractUsing the agar culture technique, we have measured the effect of granulocyte extracts GCE (and of erythrocyte-RCE and lymph node extracts-LNE) on the growth and proliferation of the committed granulocytic precursor cells, CFU-C. In addition we have determined their effects on the proliferation of the developing colony cells and on the ultimate cell production in the colonies. The results show that GCE has no effect on the growth or proliferative activity on the CFU-C. It does, however, reduce both the autoradiographic labelling indices of the developing colony cells and the net colony cellularities, acting as a cell cycle modulator. These are effects specific to the GCE since at the dose levels used, neither RCE nor LNE affected these measurements.


This item appears in the following Collection(s)

Show simple item record