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    Leukocyte migration inhibition in human pulmonary neoplasia.

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    Authors
    Vose, Brent M
    Kimber, I
    Moore, Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1977-03
    
    Metadata
    Show full item record
    Abstract
    Peripheral blood leukocytes from 65 lung cancer patients, 69 healthy donors, 33 patients with malignant disease outside the lung, and 24 patients with nonmalignant pulmonary conditions were examined for immune reactivity, as measured by the leukocyte migration inhibition assay, to antigens in homogenates of lung tumor tissue and material derived from tumor-free lung areas and a nonmalignant lung lesion. A low level of reactivity with apparent specificity was detected in the lung cancer patient group, with 17/52 showing migration inhibition with extracts of lung tumor tissue. Reactivity was also detectable in this group against homogenates of tumor-free lung and nonmalignant lung lesion. The data supported the conclusion that sensitization at least in some patients with lung cancer might be directed not only against tumor-specific antigens but also against antigens of less confined disease association.
    Citation
    Leukocyte migration inhibition in human pulmonary neoplasia. 1977, 58 (3):483-8 J Natl Cancer Inst
    Journal
    Journal of the National Cancer Institute
    URI
    http://hdl.handle.net/10541/139095
    PubMed ID
    839553
    Type
    Article
    Language
    en
    ISSN
    0027-8874
    Collections
    All Paterson Institute for Cancer Research

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