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    Interaction of aminoacridines with nucleic acids. A pulse-radiolysis study.

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    Authors
    Buchanan, J D
    Power, D M
    Phillips, G O
    Davies, J Vernon
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester.
    Issue Date
    1978-06
    
    Metadata
    Show full item record
    Abstract
    Pulse radiolysis has been used to study the interaction of aminoacridines with nucleic acids. The data confirm that there are two modes of binding. These are: a weak interaction which has a maximum binding ratio of one site per dye; and a strong binding process effected by both electrostatic and Van der Waals interactions. The limit of this latter, strong binding mode is approximately six sites per dye. The radiation-induced transient absorption spectrum of benzoflavine is characterized by a pronounced bleaching at 440 nm, which is quenched by the addition of nucleic acids. Mechanisms have been proposed for the reactions of both eaq-and .OH with benzoflavine which account both for the observed bleaching of benzoflavine solutions and for the protective effect of nucleic acids. It is proposed that eaq-reacts with benzoflavine to form a stable benzoflavine semiquinone radical and that .OH reacts with subsequent formation of a very stable benzoflavine hydroxycyclohexadienyl radical.
    Citation
    Interaction of aminoacridines with nucleic acids. A pulse-radiolysis study. 1978, 33 (6):551-62 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/138496
    DOI
    10.1080/09553007814550461
    PubMed ID
    308053
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553007814550461
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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