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dc.contributor.authorSalisbury, J
dc.contributor.authorO'Connor, Peter J
dc.date.accessioned2011-07-22T14:25:40Z
dc.date.available2011-07-22T14:25:40Z
dc.date.issued1976-06
dc.identifier.citationEffect of treatment in vivo with N,N-dimethylnitrosamine or methyl methanesulphonate on the cytoplasmic DNA polymerase of regenerating rat liver. 1976, 3 (6):1561-8 Nucleic Acids Resen
dc.identifier.issn0305-1048
dc.identifier.pmid183185
dc.identifier.doi10.1093/nar/3.6.1561
dc.identifier.urihttp://hdl.handle.net/10541/136614
dc.description.abstractA 10-16 fold increase in rat liver cytoplasmic DNA polymerase (DNA polymerase-alpha) was observed by 24 hrs after two thirds partial hepatectomy. Injection of either N,N-dimethylnitrosamine (DMN) or methyl methanesulphonate (MMS) At 6 or 12 hrs after partial hepatectomy completely inhibited this increased production of polymerase, but when given at 20 hours they had less effect. Neither compound altered the molecular size distribution of the enzyme. These data indicate that the lowered levels of DNA polymerase-alpha could play a major role in the reduction in DNA synthesis which occurs after carcinogen treatment.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCytoplasm
dc.subject.meshDNA Nucleotidyltransferases
dc.subject.meshDimethylnitrosamine
dc.subject.meshLiver
dc.subject.meshLiver Regeneration
dc.subject.meshMale
dc.subject.meshMesylates
dc.subject.meshMethyl Methanesulfonate
dc.subject.meshMolecular Weight
dc.subject.meshNitrosamines
dc.subject.meshRats
dc.titleEffect of treatment in vivo with N,N-dimethylnitrosamine or methyl methanesulphonate on the cytoplasmic DNA polymerase of regenerating rat liver.en
dc.typeArticleen
dc.identifier.journalNucleic Acids Researchen
html.description.abstractA 10-16 fold increase in rat liver cytoplasmic DNA polymerase (DNA polymerase-alpha) was observed by 24 hrs after two thirds partial hepatectomy. Injection of either N,N-dimethylnitrosamine (DMN) or methyl methanesulphonate (MMS) At 6 or 12 hrs after partial hepatectomy completely inhibited this increased production of polymerase, but when given at 20 hours they had less effect. Neither compound altered the molecular size distribution of the enzyme. These data indicate that the lowered levels of DNA polymerase-alpha could play a major role in the reduction in DNA synthesis which occurs after carcinogen treatment.


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