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    Effect of treatment in vivo with N,N-dimethylnitrosamine or methyl methanesulphonate on the cytoplasmic DNA polymerase of regenerating rat liver.

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    Authors
    Salisbury, J
    O'Connor, Peter J
    Issue Date
    1976-06
    
    Metadata
    Show full item record
    Abstract
    A 10-16 fold increase in rat liver cytoplasmic DNA polymerase (DNA polymerase-alpha) was observed by 24 hrs after two thirds partial hepatectomy. Injection of either N,N-dimethylnitrosamine (DMN) or methyl methanesulphonate (MMS) At 6 or 12 hrs after partial hepatectomy completely inhibited this increased production of polymerase, but when given at 20 hours they had less effect. Neither compound altered the molecular size distribution of the enzyme. These data indicate that the lowered levels of DNA polymerase-alpha could play a major role in the reduction in DNA synthesis which occurs after carcinogen treatment.
    Citation
    Effect of treatment in vivo with N,N-dimethylnitrosamine or methyl methanesulphonate on the cytoplasmic DNA polymerase of regenerating rat liver. 1976, 3 (6):1561-8 Nucleic Acids Res
    Journal
    Nucleic Acids Research
    URI
    http://hdl.handle.net/10541/136614
    DOI
    10.1093/nar/3.6.1561
    PubMed ID
    183185
    Type
    Article
    Language
    en
    ISSN
    0305-1048
    ae974a485f413a2113503eed53cd6c53
    10.1093/nar/3.6.1561
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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