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dc.contributor.authorHendry, Jolyon H
dc.contributor.authorRosenberg, I
dc.contributor.authorGreene, D
dc.contributor.authorStewart, J G
dc.date.accessioned2011-07-22T14:11:25Z
dc.date.available2011-07-22T14:11:25Z
dc.date.issued1976-08
dc.identifier.citationTolerance of rodent tails to necrosis after "daily" fractionated X rays or D-T neutrons. 1976, 49 (584):690-9 Br J Radiolen
dc.identifier.issn0007-1285
dc.identifier.pmid953388
dc.identifier.doi10.1259/0007-1285-49-584-690
dc.identifier.urihttp://hdl.handle.net/10541/136611
dc.description.abstractThe rat tail has been used as a model system to study the necrosis of an organized tissue following fractionated doses of collimated D-T neutrons or 290 kV X rays. RBE values for tail tolerance - 10 per cent of tails necrosing after the early skin reactions - rise from about 1-7 (single doses) to about 3-1 (16 fractions in 22 days). Neutron tolerance doses are almost independent of fractionation from 2 to 16 fractions. The tissues at risk are shown to be rather hypoxic. Early skin reaction levels can be used to predict the fraction of tails that will necrose. Early peak reactions for a given fraction of necrotic tails were slightly higher for neutrons than for X rays, and this difference was consistent for all the dose fractionation schedules employed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFast Neutrons
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshNecrosis
dc.subject.meshOxygen
dc.subject.meshRadiation Dosage
dc.subject.meshRadiation Injuries, Experimental
dc.subject.meshRats
dc.subject.meshSkin
dc.subject.meshTail
dc.subject.meshTemperature
dc.subject.meshTime Factors
dc.subject.meshWound Healing
dc.subject.meshX-Rays
dc.titleTolerance of rodent tails to necrosis after "daily" fractionated X rays or D-T neutrons.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Department of Physics, and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Withington, Manchester 20en
dc.identifier.journalBritish Journal of Radiologyen
html.description.abstractThe rat tail has been used as a model system to study the necrosis of an organized tissue following fractionated doses of collimated D-T neutrons or 290 kV X rays. RBE values for tail tolerance - 10 per cent of tails necrosing after the early skin reactions - rise from about 1-7 (single doses) to about 3-1 (16 fractions in 22 days). Neutron tolerance doses are almost independent of fractionation from 2 to 16 fractions. The tissues at risk are shown to be rather hypoxic. Early skin reaction levels can be used to predict the fraction of tails that will necrose. Early peak reactions for a given fraction of necrotic tails were slightly higher for neutrons than for X rays, and this difference was consistent for all the dose fractionation schedules employed.


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