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    Tolerance of rodent tails to necrosis after "daily" fractionated X rays or D-T neutrons.

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    Authors
    Hendry, Jolyon H
    Rosenberg, I
    Greene, D
    Stewart, J G
    Affiliation
    Paterson Laboratories, Department of Physics, and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Withington, Manchester 20
    Issue Date
    1976-08
    
    Metadata
    Show full item record
    Abstract
    The rat tail has been used as a model system to study the necrosis of an organized tissue following fractionated doses of collimated D-T neutrons or 290 kV X rays. RBE values for tail tolerance - 10 per cent of tails necrosing after the early skin reactions - rise from about 1-7 (single doses) to about 3-1 (16 fractions in 22 days). Neutron tolerance doses are almost independent of fractionation from 2 to 16 fractions. The tissues at risk are shown to be rather hypoxic. Early skin reaction levels can be used to predict the fraction of tails that will necrose. Early peak reactions for a given fraction of necrotic tails were slightly higher for neutrons than for X rays, and this difference was consistent for all the dose fractionation schedules employed.
    Citation
    Tolerance of rodent tails to necrosis after "daily" fractionated X rays or D-T neutrons. 1976, 49 (584):690-9 Br J Radiol
    Journal
    British Journal of Radiology
    URI
    http://hdl.handle.net/10541/136611
    DOI
    10.1259/0007-1285-49-584-690
    PubMed ID
    953388
    Type
    Article
    Language
    en
    ISSN
    0007-1285
    ae974a485f413a2113503eed53cd6c53
    10.1259/0007-1285-49-584-690
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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