Acromegaly due to production of a growth hormone releasing factor by a bronchial carcinoid tumor.
AffiliationChristie Hospital and Holt Radium Institute, Manchester
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AbstractWe have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperosidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary monolayer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a production.
CitationAcromegaly due to production of a growth hormone releasing factor by a bronchial carcinoid tumor. 1979, 10 (1):61-7 Clin Endocrinol
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