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    Persistence of methylated bases in ribonucleic acid of syrian golden hamster liver after administration of dimethylnitrosamine.

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    Authors
    Margison, Geoffrey P
    Margison, J
    Montesano, R
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1979-03-01
    
    Metadata
    Show full item record
    Abstract
    1. Syrian golden hamster liver ribosomal RNA was isolated up to 96 h after administration of [14C]dimethylnitrosamine at 25 mg/kg or 2.5 mg/kg body weight. 2. The chemical alkyation products, 7-methylguanine, 3-methylcytosine, O6-methylguanosine and 1-methyladenosine, were measured after acidic or enzymic hydrolysis of the RNA to bases or mononucleosides followed by ion-exchange chromatography. 3. Between 7 and 96 h, the relative amounts of alkylation products did not change with time even though the absolute amounts fell by approx. 80% and 51% after the high and low doses respectively. 4. The results suggest that base specific excision repair does not exist for RNA alkylation products in this experimental system.
    Citation
    Persistence of methylated bases in ribonucleic acid of syrian golden hamster liver after administration of dimethylnitrosamine. 1979, 177 (3):967-73 Biochem J
    Journal
    The Biochemical Journal
    URI
    http://hdl.handle.net/10541/136433
    PubMed ID
    444213
    Type
    Article
    Language
    en
    ISSN
    0264-6021
    Collections
    All Paterson Institute for Cancer Research

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