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    Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia.

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    Authors
    Shalet, Stephen M
    Price, D
    Beardwell, Colin G
    Jones, P H
    Pearson, D
    Affiliation
    Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1979-05
    
    Metadata
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    Abstract
    We have studied the relationship between abnormalities of the growth hormone-somatomedin axis and growth in 26 children previously treated for acute lymphatic leukemia. Each child had previously received cranial irradiation, was in complete clinical and hematologic remission, and off all drugs. The mean standing height SDS of the 26 children was significantly less than normal. There was no significant difference between the mean standing height SDS, height velocity SDS, somatomedin activities, and degree of bone age retardation between the 17 children who received the higher dose of cranial irradiation (Group 1) and the nine who had the lower dose of cranial irradiation (Group II). Furthermore, there was no significant reduction in mean height velocity SDS, somatomedin activity, or bone age in either group when compared to normal age-matched controls. The peak GH responses to both insulin hypoglycemia and an arginine test were significantly lowered in Groups I and II when compared to a control group of children. We conclude that only a minority of children, who previously received cranial irradiation for ALL were clinically GH deficient and, therefore, likely to benefit from GH therapy despite the finding that the majority of these children had reduced GH responses to pharmacologic stimuli.
    Citation
    Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. 1979, 94 (5):719-22 J Pediatr
    Journal
    The Journal of Pediatrics
    URI
    http://hdl.handle.net/10541/136412
    DOI
    10.1016/S0022-3476(79)80137-7
    PubMed ID
    221628
    Type
    Article
    Language
    en
    ISSN
    0022-3476
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0022-3476(79)80137-7
    Scopus Count
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