Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia.
Affiliation
Christie Hospital and Holt Radium Institute, ManchesterIssue Date
1979-05
Metadata
Show full item recordAbstract
We have studied the relationship between abnormalities of the growth hormone-somatomedin axis and growth in 26 children previously treated for acute lymphatic leukemia. Each child had previously received cranial irradiation, was in complete clinical and hematologic remission, and off all drugs. The mean standing height SDS of the 26 children was significantly less than normal. There was no significant difference between the mean standing height SDS, height velocity SDS, somatomedin activities, and degree of bone age retardation between the 17 children who received the higher dose of cranial irradiation (Group 1) and the nine who had the lower dose of cranial irradiation (Group II). Furthermore, there was no significant reduction in mean height velocity SDS, somatomedin activity, or bone age in either group when compared to normal age-matched controls. The peak GH responses to both insulin hypoglycemia and an arginine test were significantly lowered in Groups I and II when compared to a control group of children. We conclude that only a minority of children, who previously received cranial irradiation for ALL were clinically GH deficient and, therefore, likely to benefit from GH therapy despite the finding that the majority of these children had reduced GH responses to pharmacologic stimuli.Citation
Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. 1979, 94 (5):719-22 J PediatrJournal
The Journal of PediatricsDOI
10.1016/S0022-3476(79)80137-7PubMed ID
221628Type
ArticleLanguage
enISSN
0022-3476ae974a485f413a2113503eed53cd6c53
10.1016/S0022-3476(79)80137-7
Scopus Count
Collections
Related articles
- Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function.
- Authors: Costin G
- Issue date: 1988 Aug
- Growth, growth hormone secretion and somatomedin C after cranial irradiation for acute lymphoblastic leukemia.
- Authors: Brauner R, Prevot C, Roy MP, Rappaport R
- Issue date: 1986
- Twenty-four-hour plasma growth hormone (GH) profiles, urinary GH excretion, and plasma insulin-like growth factor-I and -II levels in prepubertal children with chronic renal insufficiency and severe growth retardation.
- Authors: Hokken-Koelega AC, Hackeng WH, Stijnen T, Wit JM, de Muinck Keizer-Schrama SM, Drop SL
- Issue date: 1990 Sep
- Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature.
- Authors: Romshe CA, Zipf WB, Miser A, Miser J, Sotos JF, Newton WA
- Issue date: 1984 Feb
- Effect of growth hormone-releasing factor on growth hormone release in children with radiation-induced growth hormone deficiency.
- Authors: Lustig RH, Schriock EA, Kaplan SL, Grumbach MM
- Issue date: 1985 Aug