Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.
Authors
Hall, J SLeong, Hui Sun
Armenoult, L S C
Newton, G E
Valentine, Helen R
Irlam, Joely J
Möller-Levet, Carla S
Sikand, Kanwal A
Pepper, Stuart D
Miller, Crispin J
West, Catharine M L
Affiliation
Translational Radiobiology Group, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2011-03-15
Metadata
Show full item recordAbstract
Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies. This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.Citation
Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. 2011, 104 (6):971-81 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2011.66PubMed ID
21407225Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2011.66
Scopus Count
Related articles
- Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation.
- Authors: Hall JS, Taylor J, Valentine HR, Irlam JJ, Eustace A, Hoskin PJ, Miller CJ, West CM
- Issue date: 2012 Aug 7
- Methods comparison for high-resolution transcriptional analysis of archival material on Affymetrix Plus 2.0 and Exon 1.0 microarrays.
- Authors: Linton K, Hey Y, Dibben S, Miller C, Freemont A, Radford J, Pepper S
- Issue date: 2009 Jul
- Robust transcriptional tumor signatures applicable to both formalin-fixed paraffin-embedded and fresh-frozen samples.
- Authors: Chen R, Guan Q, Cheng J, He J, Liu H, Cai H, Hong G, Zhang J, Li N, Ao L, Guo Z
- Issue date: 2017 Jan 24
- Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform.
- Authors: Jackson AF, Williams A, Moffat I, Phillips SL, Recio L, Waters MD, Lambert IB, Yauk CL
- Issue date: 2013 Sep-Oct
- Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues.
- Authors: Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE
- Issue date: 2015 Dec