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    Ultrastructural morphology of three-dimensional colonies of cells derived from a hepatocellular carcinoma.

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    Authors
    Allen, Terence D
    Iype, P
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1979
    
    Metadata
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    Abstract
    Cultured hepatocellular carcinoma cells were studied during anchorage-independent growth in semi solid medium (Methocel). The regular occurrence of mitotic figures both at the surface and within the colonies precludes the possibility of such colonies being formed by re-aggregation. The estimated population doubling time in the three-dimensional (3-D) colonies is consistent with those two-dimensional of (2-D) colonies. Structures resembling bile canaliculi were observed between the closely opposed membranes from the well packed adjacent cells. Cell surface and ultrastructural features of the colonies and individual cells are presented and comparisons made with 2-D growth of normal and malignant liver cells in vitro. The formation of 3-D colonies may not only be an assay for transformed cells but also for predicting the type of tumors produced by re-innoculation of the in vitro transformed cells.
    Citation
    Ultrastructural morphology of three-dimensional colonies of cells derived from a hepatocellular carcinoma. 1979, 95 (3):225-32 J Cancer Res Clin Oncol
    Journal
    Journal of Cancer Research and Clinical Oncology
    URI
    http://hdl.handle.net/10541/136150
    DOI
    10.1007/BF00410643
    PubMed ID
    528563
    Type
    Article
    Language
    en
    ISSN
    0171-5216
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00410643
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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