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    Significance of specific-locus germ-cell mutations in mice.

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    Authors
    Bateman, A J
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1979-10
    
    Metadata
    Show full item record
    Abstract
    On the basis of a historical-control incidence of 39 mutants in 688 921 progeny (5.7 mutants/10(5) animals or 0.82 mutations/locus/10(5) gametes) proposals are made for the numbers of test progeny required when screening for possible mutagens using the specific-locus test in mice (7 loci). It is recommended that 25,000 control progeny should be included in each test, to establish homogeneity with the historical controls. This would also be the number of progeny required from treated males, unless significantly positive results had been obtained with smaller numbers. It would appear that the greater sensitivity of post-spermatogonial stages could more than compensate for practical difficulties in sampling these stages, rather than spermatogonia, in screening tests.
    Citation
    Significance of specific-locus germ-cell mutations in mice. 1979, 64 (5):345-51 Mutat Res
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10541/135966
    PubMed ID
    390380
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    Collections
    All Paterson Institute for Cancer Research

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