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dc.contributor.authorLister, T
dc.contributor.authorWhitehouse, J
dc.contributor.authorBeard, M
dc.contributor.authorPaxton, A
dc.contributor.authorBrearley, R
dc.contributor.authorBrown, L
dc.contributor.authorWrigley, P
dc.contributor.authorCrowther, Derek
dc.date.accessioned2011-07-13T11:45:25Z
dc.date.available2011-07-13T11:45:25Z
dc.date.issued1977-04
dc.identifier.citationEarly central nervous system involvement in adults with acute non-myelogenous leukaemia. 1977, 35 (4):479-83 Br J Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid265731
dc.identifier.urihttp://hdl.handle.net/10541/135963
dc.description.abstractOf 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAsparaginase
dc.subject.meshCentral Nervous System Diseases
dc.subject.meshHumans
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Metastasis
dc.subject.meshPrednisolone
dc.subject.meshRemission, Spontaneous
dc.titleEarly central nervous system involvement in adults with acute non-myelogenous leukaemia.en
dc.typeArticleen
dc.identifier.journalBritish Journal of Canceren
html.description.abstractOf 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia.


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