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    Early central nervous system involvement in adults with acute non-myelogenous leukaemia.

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    Authors
    Lister, T
    Whitehouse, J
    Beard, M
    Paxton, A
    Brearley, R
    Brown, L
    Wrigley, P
    Crowther, Derek
    Issue Date
    1977-04
    
    Metadata
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    Abstract
    Of 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia.
    Citation
    Early central nervous system involvement in adults with acute non-myelogenous leukaemia. 1977, 35 (4):479-83 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/135963
    PubMed ID
    265731
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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