• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Shalet, Stephen M
    Beardwell, Colin G
    Jones, P
    Pearson, D
    Macfarlane, I
    Issue Date
    1977-04
    
    Metadata
    Show full item record
    Abstract
    Hypothalamic-pituitary function was assessed in 20 adult subjects who were treated with cerebral irradiation for brain tumours during childhood between 8 and 32 years earlier. Nine patients showed impaired growth hormone (GH) responses to hypoglycaemia, of whom, 7 are below the third centile for standing height. All GH deficient subjects received more than 2950 rads to the hypothalamic-pituitary axis with a maximum dose of approximately 5000 rads being used in one case. Three subjects have an elevated basal serum thyroid stimulating hormone (TSH) level and 2 of these show an exaggerated TSH response to thyrotrophin releasing hormone (TRH) but no patient was clinically or biochemically hypothyroid. The rest of hypothalamic-pituitary function was essentially normal. This study shows that multiple pituitary hormone deficiencies do no develop with time when the radiation dose is below a critical level. Thus it appears that there is a gradation of radiation damage to the hypothalamic-pituitary axis which is dependent primarily on the dose received rather than the time interval after radiotherapy.
    Citation
    Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood. 1977, 84 (4):673-80 Acta Endocrinol
    Journal
    Acta Endocrinologica
    URI
    http://hdl.handle.net/10541/135962
    http://hdl.handle.net/10541/135961
    PubMed ID
    403723
    Type
    Article
    Language
    en
    ISSN
    0001-5598
    Collections
    All Christie Publications
    All Christie Publications

    entitlement

    Related articles

    • Pituitary hormone responses to hypothalamic releasing hormones in acromegaly.
    • Authors: Cantalamessa L, Reschini E, Catania A, Giustina G
    • Issue date: 1976 Dec
    • Serum thyrotrophin, prolactin and growth hormone, response to TRH during oestrogen treatment.
    • Authors: Rutlin E, Haug E, Torjesen PA
    • Issue date: 1977 Jan
    • Long-term effects of allogeneic bone marrow transplantation (BMT) on pituitary, gonad, thyroid and adrenal function in adults.
    • Authors: Kauppila M, Koskinen P, Irjala K, Remes K, Viikari J
    • Issue date: 1998 Aug
    • Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities.
    • Authors: Maghnie M, Triulzi F, Larizza D, Preti P, Priora C, Scotti G, Severi F
    • Issue date: 1991 Jul
    • Long-Term Effect of Cranial Radiotherapy on Pituitary-Hypothalamus Area in Childhood Acute Lymphoblastic Leukemia Survivors.
    • Authors: Follin C, Erfurth EM
    • Issue date: 2016 Sep
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.