Fractionated dose studies with X-rays and various alkylating agents in P388 mouse lymphoma cells.
AffiliationPaterson Laboratories, Christie Hospital & Holt Radium Institute, Wilmslow Road, Manchester M20 9BX, UK.
MetadataShow full item record
AbstractThe fractionated dose technique has been used in P388F cells to examine the effects of X-rays and four alkylating agents on survival and induction of 5-iodo-2-deoxyuridine (IudR) resistant variants. Fractionation intervals up to 5 1/2 h were used for X-rays and for the alkylating agents up to 192 h. Fractionation of the X-ray dose resulted in a sparing effect for survival and variant induction. A sparing effect was also observed for survival after treatment with alkylating agents. However, variant frequencies were observed as large as or greater than those produced by the full doses of alkylating agents. For such agents this would suggest that survival and variant induction are independent events. Differences in the effects of X-rays and alkylating agents cannot be explained by differences in growth rate or the recovery of viability after treatment.
CitationFractionated dose studies with X-rays and various alkylating agents in P388 mouse lymphoma cells. 1981, 2 (3):205-11 Carcinogenesis
- The induction of thymidine- and IUdR-resistant variants in P388 mouse lymphoma cells by x-rays, UV and mono- and bi-functional alkylating agents.
- Authors: Anderson D, Fox M
- Issue date: 1974 Oct
- DNA-directed alkylating agents. 6. Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogues of pibenzimol (Hoechst 33258)
- Authors: Gravatt GL, Baguley BC, Wilson WR, Denny WA
- Issue date: 1994 Dec 9
- Potentiation of antitumor drug action by centrophenoxine: specificity.
- Authors: Sladek NE
- Issue date: 1977 May
- Nicotinamide as a repair inhibitor in vivo: studies using single and fractionated X-ray doses in mouse skin and kidneys.
- Authors: Rojas A, Denekamp J, Johns H, Kjellen E, Tsang R, Nilsson P, Stratford MR, Dennis MF, Joiner MC
- Issue date: 1996 Apr
- Quantitative analyses of radiation- and chemical-induced lethality and mutagenesis in Chinese hamster ovary cells.
- Authors: Hsie AW, O'Neill JP, Couch DB, SanSebastian JR, Brimer PA, Machanoff R, Fuscoe JC, Riddle JC, Li AP, Forbes NL, Hsie MH
- Issue date: 1978 Dec