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    Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures.

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    Authors
    Dexter, T Michael
    Testa, Nydia G
    Allen, Terence D
    Rutherford, T
    Scolnick, E
    Affiliation
    Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington M20 9BX, Manchester England
    Issue Date
    1981-10
    
    Metadata
    Show full item record
    Abstract
    In long-term marrow cultures, proliferation and differentiation of hemopoietic stem cells occurs for several months. Normally, only the most primitive erythroid progenitor cells are produced (the BFU-E). Following treatment with anemic mouse serum (AMS) or normal mouse serum plus erythropoietin, the BFU-E mature into CFU-E, which then go to produce mature nonnucleated red cells. This development is associated with the production of adult type hemoglobin. Furthermore, erythropoiesis and granulopoiesis occur in association with discrete cellular elements of the adherent cell layer in the long-term culture. Following treatment with AMS, erythropoiesis is enhanced while granulopoiesis is depressed, with no apparent competition at the stem cell or progenitor cell level.
    Citation
    Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures. 1981, 58 (4):699-707 Blood
    Journal
    Blood
    URI
    http://hdl.handle.net/10541/135904
    PubMed ID
    7272501
    Type
    Article
    Language
    en
    ISSN
    0006-4971
    Collections
    All Paterson Institute for Cancer Research

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