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    The radial distribution of fibroblastic colony-forming units in mouse femoral marrow.

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    Authors
    Xu, Cheng Xiong
    Hendry, Jolyon H
    Issue Date
    1981-09
    
    Metadata
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    Abstract
    The distribution of fibroblastic colony forming units (CFU-F) in mouse femoral marrow was investigated using a method which separates bone marrow cells into two regional fractions of varying size. It is shown that the concentration of CFU-F decreases almost linearly from the femoral axis (800-1,000 CFU-F per 10(7) bone marrow cells) to the bone surface (300 CFU-F per 10(7) cells). When irradiated axial or marginal cells were added into cultures as feeder cells, the colony numbers produced by both axial or marginal CFU-F were increased by about 50% and the higher concentration in the axial regions remained. The survival curve for CFU-F in both regions was characterised by a Do value of 1.54 +/- 0.11 Gy and an extrapolation number of 2.60 +/- 0.38. The results are compared to the distributions of haemopoietic stem cells and committed progenitor cells.
    Citation
    The radial distribution of fibroblastic colony-forming units in mouse femoral marrow. 1981, 35 (4):119-22 Biomedicine
    Journal
    Biomedicine
    URI
    http://hdl.handle.net/10541/135903
    PubMed ID
    7295861
    Type
    Article
    Language
    en
    ISSN
    0300-0893
    Collections
    All Paterson Institute for Cancer Research

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