C1q binding activity in the sera of patients with chronic lung diseases.
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, UKIssue Date
1981-07
Metadata
Show full item recordAbstract
Sera from patients with chronic lung diseases were tested for the presence of immune complexes (ICs) by the 125I-C1q-binding assay. Contrary to earlier reports, modification of the test system by addition of heparin decreased rather than increased the ability of the test to discriminate between control and pathological sera. Using the unmodified system, elevated C1q-binding activity (C1qBA) was found in patients with asthma (18%), chronic bronchitis (18%), sarcoidosis (18%), fibrosing alveolitis (50%), bronchogenic carcinoma (52%) and bronchiectasis (67%). Studies with the reducing agent 2-mercaptoethanol (2-ME) suggested a role for IgM rheumatoid factor (RF) and/or IgG-containing complexes in the C1q-reactive material of sera from patients with bronchiectasis and bronchogenic carcinoma. In the latter two groups, C1qBA was found to correlate with serum levels of IgG and IgA but not with C3 and C4. A weak condition between levels of C-reactive protein (CRP) and C1qBA was found in the bronchogenic carcinoma group. Carcinoembryonic antigen (CEA) levels were elevated in all groups studied but no correlation with C1qBA was demonstrated, suggesting that CEA and CEA-ICs, if present, do not have an influence on the C1qBA of such sera. The results indicate that elevated serum C1qBA is a concomitant of both chronic inflammatory and neoplastic diseases of the lung but the extent of any similarity in the non-immunoglobulin components of the immune complexes in the respective conditions remains unknown.Citation
C1q binding activity in the sera of patients with chronic lung diseases. 1981, 45 (1):18-28 Clin Exp ImmunolJournal
Clinical and Experimental ImmunologyPubMed ID
6975678Type
ArticleLanguage
enISSN
0009-9104Collections
Related articles
- Heterogeneity of circulating immune complexes in chronic lung diseases.
- Authors: Cooper KM, Moore M
- Issue date: 1982 Apr
- Reactivity of low molecular weight material in cellular immune complex assays.
- Authors: Cooper KM, Moore M
- Issue date: 1983 May
- C1q-latex assay for immune complexes. Complexes that react with both C1q and monoclonal rheumatoid factor in lupus erythematosus and lung cancer.
- Authors: Medof ME
- Issue date: 1982 May
- [Carcinoembryonic antigen (CEA) in the blood serum of patients with bronchogenic carcinoma and selected diseases of the respiratory tract].
- Authors: Szklarz E, Gawlikowski W
- Issue date: 1989 Apr
- A comparative study of complement components in polyethylene glycol precipitated immune complexes from patients with ovarian cancer and patients with rheumatoid arthritis.
- Authors: Mooney NA, Hay FC, Poulton TA
- Issue date: 1983 Jun