Show simple item record

dc.contributor.authorChu, Yung-Hua
dc.contributor.authorCraig, Alister W
dc.contributor.authorO'Connor, Peter J
dc.date.accessioned2011-07-12T17:23:33Z
dc.date.available2011-07-12T17:23:33Z
dc.date.issued1981-06
dc.identifier.citationRepair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. 1981, 43 (6):850-5 Br J Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid6788062
dc.identifier.urihttp://hdl.handle.net/10541/135868
dc.description.abstractPretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose.
dc.language.isoenen
dc.subject.meshAdenine
dc.subject.meshAflatoxin B1
dc.subject.meshAflatoxins
dc.subject.meshAnimals
dc.subject.meshDNA Repair
dc.subject.meshDimethylnitrosamine
dc.subject.meshGuanine
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshRats
dc.subject.meshStimulation, Chemical
dc.titleRepair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Instute, Manchester M20 9BXen
dc.identifier.journalBritish Journal of Canceren
html.description.abstractPretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose.


This item appears in the following Collection(s)

Show simple item record