Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.
dc.contributor.author | Chu, Yung-Hua | |
dc.contributor.author | Craig, Alister W | |
dc.contributor.author | O'Connor, Peter J | |
dc.date.accessioned | 2011-07-12T17:23:33Z | |
dc.date.available | 2011-07-12T17:23:33Z | |
dc.date.issued | 1981-06 | |
dc.identifier.citation | Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. 1981, 43 (6):850-5 Br J Cancer | en |
dc.identifier.issn | 0007-0920 | |
dc.identifier.pmid | 6788062 | |
dc.identifier.uri | http://hdl.handle.net/10541/135868 | |
dc.description.abstract | Pretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose. | |
dc.language.iso | en | en |
dc.subject.mesh | Adenine | |
dc.subject.mesh | Aflatoxin B1 | |
dc.subject.mesh | Aflatoxins | |
dc.subject.mesh | Animals | |
dc.subject.mesh | DNA Repair | |
dc.subject.mesh | Dimethylnitrosamine | |
dc.subject.mesh | Guanine | |
dc.subject.mesh | Liver | |
dc.subject.mesh | Male | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Stimulation, Chemical | |
dc.title | Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. | en |
dc.type | Article | en |
dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Instute, Manchester M20 9BX | en |
dc.identifier.journal | British Journal of Cancer | en |
html.description.abstract | Pretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose. |